Exosomes are small extracellular vesicles that play a significant role in cell communication and have shown promise in the treatment of various diseases, including stroke. Recent research highlights the potential of exosomes in stroke therapy due to their ability to deliver therapeutic molecules directly to the affected area.
One of the key focuses of recent studies has been the development of efficient purification methods for exosomes, which is crucial for their therapeutic application. The document discusses several purification techniques, including ultracentrifugation, ExoQuick™ exosome precipitation, and miRCURY™ exosome extraction kits. These methods aim to isolate high-purity exosomes from cell culture conditioned medium.
The therapeutic potential of exosomes in stroke treatment lies in their ability to modulate inflammation and support tissue regeneration. They can deliver neuroprotective and neurorestorative molecules, making them a promising tool in the fight against stroke-related damage.
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References:
- Mauldin, P.D., et al. (2024). Design of the economic evaluation for the Interventional Management of Stroke (III) trial. Int. J. Stroke, 3, 138-144. Emerging Roles of Exosomes in Stroke Therapy [CrossRef] [PubMed]
- Tsao, C.W., et al. (2022). Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association. Circulation, 145, e153-e639. Emerging Roles of Exosomes in Stroke Therapy [PubMed]
- Helwa, I., et al. (2017). A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents. PLoS ONE, 12, e0170628. Emerging Roles of Exosomes in Stroke Therapy [CrossRef]